For almost half a century, ligation using clips has been a standard method of obtaining hemostasis and duct closure quickly and inexpensively. During this period, Ligaclip has become the most widely used clip applier based on its performance in providing reliable hemostasis. This study reviews the application of Ligaclip and Ligamax in various surgical procedures and compares them to other devices in performance features that are critical in ensuring hemostasis and vessel sealing.