纳米载体
药物输送
生物相容性
透明质酸
纳米技术
靶向给药
背景(考古学)
材料科学
化学
纳米医学
药理学
纳米颗粒
医学
有机化学
生物
解剖
古生物学
作者
Chaoping Fu,X. D. Cai,Silin Chen,Hua Yu,Ying Fang,Xiao-Chen Feng,Liming Zhang,Changyong Li
出处
期刊:Polymers
[MDPI AG]
日期:2023-05-16
卷期号:15 (10): 2317-2317
被引量:16
标识
DOI:10.3390/polym15102317
摘要
Hyaluronic acid (HA), a main component of the extracellular matrix, is widely utilized to deliver anticancer drugs due to its biocompatibility, biodegradability, non-toxicity, non-immunogenicity and numerous modification sites, such as carboxyl and hydroxyl groups. Moreover, HA serves as a natural ligand for tumor-targeted drug delivery systems, as it contains the endocytic HA receptor, CD44, which is overexpressed in many cancer cells. Therefore, HA-based nanocarriers have been developed to improve drug delivery efficiency and distinguish between healthy and cancerous tissues, resulting in reduced residual toxicity and off-target accumulation. This article comprehensively reviews the fabrication of anticancer drug nanocarriers based on HA in the context of prodrugs, organic carrier materials (micelles, liposomes, nanoparticles, microbubbles and hydrogels) and inorganic composite nanocarriers (gold nanoparticles, quantum dots, carbon nanotubes and silicon dioxide). Additionally, the progress achieved in the design and optimization of these nanocarriers and their effects on cancer therapy are discussed. Finally, the review provides a summary of the perspectives, the lessons learned so far and the outlook towards further developments in this field.
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