Endometriosis caused by retrograde menstruation: now demonstrated by DNA evidence

Pelvic endometriosis is not an enigmatic disease as it often is portrayed in many publications. In fact, its pathophysiology is more straightforward than many other chronic inflammatory conditions (1). Endometriosis is a systemic and chronic inflammatory disease that originates from the endometrium, the intracavitary mucosa of the uterus (1). What separates endometriosis from other chronic inflammatory diseases is its dependence on estrogen for its key biologic properties, that is, persistence, inflammation, and associated fibrosis and remodeling of neighboring tissues.