Lewis Acid Catalyzed [3+3] Annulation/Aldol Condensation in Water: One Pot Synthesis of (E,E)‐4,6‐Bis(styryl)‐Pyrimidines

Abstract An efficient and facile one pot synthesis of ( E,E )‐4,6‐bis(styryl)‐pyrimidines has been developed. It involves one pot two step reactions in environmentally benign solvent water, where first step involves pyrimidine ring formation from acetylacetone and urea via [3+3] annulation, followed by aldol condensation with differently substituted aromatic aldehyde to give desired ( E,E )‐4,6‐bis(styryl)‐pyrimidines in moderate to good yields.