多路复用
癌症
癌症检测
生物标志物
计算生物学
生物
计算机科学
医学
生物信息学
生物化学
内科学
作者
Xiangjie Luo,Bilun Kang,Xiaoqin Chi,Hui Xiong,Dongxia Chen,Yifan Fan,Lingxuan Li,Limin Chen,Ao Li,Jinhao Gao,Hongyu Lin
标识
DOI:10.1002/anie.202211189
摘要
Abstract Simultaneous detection of multiple biomarkers in complex environments is critical for the in‐depth exploration of different biological processes, which is challenging for many current analytical methods due to various limitations. Herein, we report a strategy of 19 F barcoding which takes the advantages of 19 F's high magnetic resonance (MR) sensitivity, prompt signal response to environmental changes, negligible biological background, quantitative signal output, and multiplex capacity. A set of 19 F‐barcoded sensors responding to different biomarkers involved in organ injury and cancer are designed, synthesized, and characterized. With these sensors, we accomplish concurrent assessment of different biomarkers in the samples collected from the mice with drug‐induced liver/kidney injury or tumor, illustrating the feasibility of this approach for multiplexed detection of different biomarkers in complex environments during various biological processes.
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