Recent Advancement In Microneedle Based Transdermal Patch

Transdermal patches based on microneedles hold the potential to increase the delivery of medicinal drugs and vaccinations through the skin while also removing biofluids for point-of-care diagnostics. Microneedle arrays have two advantages over hypodermic needles: they can be used for blood collection or drug delivery in an easy and painless manner. By altering the environment of fluid collection and subcutaneous drug delivery, the development of the required microneedle fabrication techniques has the potential to have a significant impact on the health care delivery system. The microelectronics industry uses metals, silicon, and polymers to produce needle designs with feature sizes ranging from sub-micron to millimetre. Microneedles have been produced using a variety of subtractive and additive manufacturing techniques, but the development of microneedle-based systems using conventional subtractive methods has been constrained by the limitations and high cost of microfabrication technology and additive manufacturing processes such as 3D printing. The present article provides an overview of microneedle systems applications, disease targeted designs, material selection, and manufacturing methods, microneedles under preclinical study into the market, and patents available. Keywords: Microneedle, Transdermal drug delivery, Targeted disease