神经保护
再生(生物学)
脊髓
神经科学
线粒体
脊髓损伤
变性(医学)
生物
中枢神经系统
氧化应激
细胞生物学
医学
病理
内分泌学
作者
Cheng Li,Baochang Cai,Dezhi Lu,Hong Zeng
标识
DOI:10.1016/j.mito.2023.01.009
摘要
Mitochondrial dysfunction occurs in the early stage of axonal degeneration after spinal cord injury and involves oxidative stress, energy deficiency, imbalance of mitochondrial dynamics, etc., which play a key role in axonal degeneration and regeneration under physiological and pathological conditions. Failure of axonal regeneration can lead to long-term structural and functional damage. Several recent studies have shown that improved mitochondrial energy metabolism provides conditions for axonal regeneration and central nervous system repair. Here, we describe the role of mitochondrial energy metabolism in neuroprotection and axonal regeneration after spinal cord injury and review recent advances in targeted mitochondrial therapy.
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