Discovery of new imidazole[1,2-a] pyridine derivatives as CDK9 inhibitors: Design, synthesis and biological evaluation

Colorectal cancer (CRC) is highly aggressive and extensive malignancy. Presently, targeting transcriptional regulation cyclin-dependent kinase 9 (CDK9) is a promising therapeutic treatment. Herein, twenty-five compounds (LA1~LA13, LB1~LB12) were designed and...