免疫学
免疫系统
细胞因子
过敏
过敏性炎症
免疫球蛋白E
疾病
过敏反应
白细胞介素4
发病机制
生物
白细胞介素
医学
抗体
病理
作者
Mohamed J. Saadh,Mohammed A. Alfattah,Ahmed H. Ismail,Beshir Saeed,Hazem M. Abbas,Nabila F. Elashmawy,George Hashim,Khatib Sayeed Ismail,Mabrouk A. Abo‐Zaid,Hisham Ali Waggiallah
标识
DOI:10.1016/j.intimp.2024.111825
摘要
In recent decades, allergic diseases subsequent from an IgE-mediated response to specific allergens have become a progressively public chronic disease worldwide. They have shaped an important medical and socio-economic burden. A significant proportion of allergic disorders are branded via a form 2 immune response relating Th2 cells, type 2 natural lymphoid cells, mast cells and eosinophils. Interleukin-21 (IL-21) is a participant of the type-I cytokine family manufactured through numerous subsets of stimulated CD4+ T cells and uses controlling properties on a diversity of immune cells. Increasingly, experimental sign suggests a character for IL-21 in the pathogenesis of numerous allergic disorders. The purpose of this review is to discuss the biological properties of IL-21 and to summaries current developments in its role in the regulation of allergic disorders.
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