Combined effects and potential mechanisms of volatile organic compounds on thyroid disease in the US population: An integrated epidemiological and computational toxicology study

Positive associations between blood Dibromochloromethane and Chloroform levels and thyroid disease were observed. Dibromochloromethane interacts with core targets such as MTOR, NOS3, and SLC9A1, influencing thyroid disease progression. With the widespread exposure to VOCs worldwide, this will deepen and enrich our understanding of the potential mechanism of Dibromochloromethane in thyroid disease and provide a theoretical basis for subsequent studies.