作者
Alexander Oldroyd,Jeffrey P. Callen,Hector Chinoy,Lorinda Chung,David Fiorentino,Patrick Gordon,Pedro Machado,Neil McHugh,Albert Selva-O’Callaghan,Jens Schmidt,Sarah Tansley,Ruth Ann Vleugels,Victoria P. Werth,Anthony A. Amato,Helena Andersson,Lilia Andrade-Ortega,Dana P. Ascherman,Olivier Benveniste,Lorenzo Cavagna,Christina Charles-Shoeman,Benjamin F. Chong,Lisa Christopher‐Stine,Jennie T. Clarke,Emma Crosbie,Philip Crosbie,Sonye K. Danoff,Maryam Dastmalchi,Marjolein Visser,Paul F. Dellaripa,Louise Pyndt Diederichsen,Mazen M. Dimachkie,Erik Ensrud,Floranne C. Ernste,D. Gareth Evans,Manabu Fujimoto,Ignacio Garcı́a-De La Torre,Abraham García-Kutzbach,Zoltán Griger,Latika Gupta,Marie Hudson,Florenzo Iannone,David Isenberg,Joseph L. Jorizzo,H. J. Kurtz,Masataka Kuwana,Vidya Limaye,Ingrid E. Lundberg,Andrew L. Mammen,H. Mann,Frank Mastaglia,Lorna McWilliams,Christopher A. Mecoli,Federica Meloni,Frederick W. Miller,Siamak Moghadam-Kia,Sergey Moiseev,Yoshinao Muro,Melinda Nagy‐Vincze,Clive Nayler,Merrilee Needham,Ichizo Nishino,Chester V. Oddis,Julie J Paik,Joost Raaphorst,Lisa G. Rider,Jorge Rojas-Serrano,Lesley Ann Saketkoo,Adam Schiffenbauer,Samuel Katsuyuki Shinjo,Vineeta Shobha,Yeong‐Wook Song,Tania Tillett,Yves Troyanov,Anneke J. van der Kooi,Mónica Vázquez-Del Mercado,Jiří Vencovský,Qian Wang,Steven R. Ytterberg,Rohit Aggarwal
摘要
Adult-onset idiopathic inflammatory myopathy (IIM) is associated with an increased cancer risk within the 3 years preceding and following IIM onset. Evidence- and consensus-based recommendations for IIM-associated cancer screening can potentially improve outcomes. This International Guideline for IIM-Associated Cancer Screening provides recommendations addressing IIM-associated cancer risk stratification, cancer screening modalities and screening frequency. The international Expert Group formed a total of 18 recommendations via a modified Delphi approach using a series of online surveys. First, the recommendations enable an individual patient's IIM-associated cancer risk to be stratified into standard, moderate or high risk according to the IIM subtype, autoantibody status and clinical features. Second, the recommendations outline a 'basic' screening panel (including chest radiography and preliminary laboratory tests) and an 'enhanced' screening panel (including CT and tumour markers). Third, the recommendations advise on the timing and frequency of screening via basic and enhanced panels, according to risk status. The recommendations also advise consideration of upper or lower gastrointestinal endoscopy, nasoendoscopy and 18F-FDG PET-CT scanning in specific patient populations. These recommendations are aimed at facilitating earlier IIM-associated cancer detection, especially in those who are at a high risk, thus potentially improving outcomes, including survival.