化学
斯托克斯位移
糖复合物
牛血清白蛋白
环加成
连接器
光化学
铜
分子内力
叠氮化物
荧光
组合化学
发色团
点击化学
立体化学
有机化学
催化作用
操作系统
物理
量子力学
生物化学
计算机科学
作者
Claúdia Bezerra da Silva,Luana Silva,Natalí Pires Debia,Otávio Augusto Chaves,Diogo S. Lüdtke,Fabiano Severo Rodembusch
摘要
This study presents the synthesis of novel glycoconjugates by connecting benzazole and carbohydrate units with a 1,2,3-triazole linker. A simple synthetic route employing a copper(I) catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) was utilized. The synthesized compounds exhibit excited-state intramolecular proton transfer (ESIPT), resulting in longer wavelength emission with a significantly large Stokes shift (∼10 000 cm-1). These compounds show potential as chemical sensors due to their ability to detect Cu2+ ions, causing a decrease in fluorescence emission (turn-off effect). Additionally, they demonstrate strong interaction with proteins, exemplified by their interaction with bovine serum albumin (BSA) as a model protein.
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