蛋白磷酸酶2
磷酸酶
转录组
细胞生物学
信号转导
化学
PI3K/AKT/mTOR通路
磷酸化
蛋白激酶B
细胞信号
生物
生物化学
基因表达
基因
作者
Shunta Ikeda,Koichi Sato,Takashi Ohama
标识
DOI:10.1016/j.bbrc.2023.149148
摘要
Protein phosphatase 2A (PP2A) is an essential serine/threonine protein phosphatase that belongs to the type2A protein phosphatase family with PP4 and PP6. PP2A functions as a trimeric holoenzyme, and the composition of the trimer is regulated by the methyl-esterification (methylation) of PP2A. Demethylation of PP2A is catalyzed by protein phosphatase methyl-esterase-1 (PME-1). Despite the physiological and pathophysiological importance of PME-1, the impact of changes in PME-1 expression on the transcriptome has not been reported. This study provides transcriptome data to gain a comprehensive understanding of the effects of PME-1 knockout on intracellular signaling of mouse embryonic fibroblasts. Our data showed that PME-1 suppresses inflammatory signaling, activates PI3K/Akt signaling, and promotes epithelial-mesenchymal transition.
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