STIMULATION OF HUMAN DERMAL FIBROBLASTS CHONDROGENIC DIFFERENTIATION FOR TISSUE ENGINEERING OF HYALINE CARTILAGE

This work is devoted to the possibility of human dermal fibroblasts chondrogenic differentiation using the TGF-β3 and SOX9 recombinant proteins and lentiviral vectors carrying sequences of the Tgf-β3 and Sox9 genes. It has been shown that the use of the TGF-β3 protein and vector with the Sox9 gene makes it possible to increase the expression of associated with chondrogenesis genes in fibroblasts.