Preparation of microspheres using poly-3-hydroxybutyrate biopolymer and its characterization

Controlled drug release Drug encapsulation Gentamicin Poly-3-hydroxybutyrate Preparation of microsphere using poly-3-hydroxy butyrate by solvent evaporation technique (PHB) Characterization of PHB microsphere by SEM and FTIR Size of microsphere was found to be 2μm Encapsulation of PHB microsphere with BSA and Gentamicin and the encapsulation efficiency was 94.3% and 90.27% respectively Studies on drug release from PHB microspheres revealed initial burst release followed by controlled drug release in vitro PHB microspheres were found to be non-toxic when tested for cytotoxicity using 3T3L1 cell line in vitro O n l i n e C o p y