先天免疫系统
生物
DNA
细胞生物学
胞浆
钻机-I
免疫系统
佐剂
Ⅰ型干扰素
干扰素
信号转导
免疫学
免疫
遗传学
生物化学
酶
作者
Xiao Dong Li,Jiaxi Wu,Daxing Gao,Hua Wang,Lijun Sun,Zhijian J. Chen
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2013-09-20
卷期号:341 (6152): 1390-1394
被引量:862
标识
DOI:10.1126/science.1244040
摘要
Alarm Bells The presence of DNA in the cytosol of mammalian cells is a danger signal, indicating, for example, that a DNA-containing virus has infected the cell. This signal triggers an innate immune response, which involves the expression of type I interferons, and is critical for antiviral immunity and responses to DNA vaccines. Cyclic GMP-AMP synthase (cGAS) was recently identified as a sensor of cytosolic DNA. Li et al. (p. 1390 , published online 29 August) now use knockout mice to provide genetic evidence that, in multiple cell types, cGAS is the primary DNA sensor required for the type I interferon response in vivo.
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