Clerodane diterpenoids with anti-inflammatory and synergistic antibacterial activities from Tinospora crispa

Compounds 5 and 7 exhibited nitric oxide release inhibitory activities with IC 50 values of 7.5 and 10.6 μM, respectively, and compounds 9 and 14 at the sub-MIC level significantly decreased the MIC of oxacillin against MRSA from 32.0 to 1.0 and 0.5 μg mL −1 , respectively.