粒体自噬
帕金
品脱1
自噬
秀丽隐杆线虫
神经保护
细胞生物学
神经毒性
溶酶体
β淀粉样蛋白
转基因
毒性
生物
化学
药理学
帕金森病
生物化学
细胞凋亡
医学
疾病
基因
内科学
酶
有机化学
肽
作者
Tingting Yang,Xiaotong Zhao,Yanqing Zhang,Junbo Xie,Aimin Zhou
标识
DOI:10.1016/j.scitotenv.2020.136953
摘要
This study aims to investigate the neuroprotective effects of 6‴-feruloylspinosin (6-FS), one of the main active flavonoid components in Sour Jujube seeds, on beta-amyloid (Aβ) protein transgenic Caenorhabditis elegans (GMC101) and PC12 cells, and determine the molecular mechanism of its action. We found that 6-FS could ameliorate the progression of the Alzheimer's disease (AD) phenotype by delaying the aging, decreasing the rate of paralysis, enhancing resistance to heat stress, and increasing the chemotaxis ability, and promotes autophagy activity though autophagy/lysosome pathway in GMC101. Furthermore, 6-FS reduced Aβ-induced toxicity by inhibiting the deposition of Aβ and the aggregated proteins, increasing the level of mitophagy in PC12 through promoting the expression of Pink1/Parkin in the mitophagy pathway. Our findings suggest that 6-FS may be used as a medicinal supplement for treating AD.
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