Schizophrenia and depression are mental disorders with wide range of psychiatric manifestations

Objectives: The present study was performed to the assess the levels of thyroid profile and mineral profile in patients of schizophrenia & depression.Material & Methods: 50 patients diagnosed for schizophrenia & 50 with depression visited the Outpatient Department (OPD) of Department of Psychiatric at Mahatma Gandhi Medical College & Hospital, Jaipur were enrolled for the study based on the predefined inclusion and exclusion criteria.Observations: TSH levels (P=0.019) were significantly higher in the schizophrenia group whereas T 3 (P=0.004)&T 4 (P=0.001)values were significantly lower, serum Ca levels were lower (P= 0.000).serum Po 4 levels were significantly higher.(P=0.000)decrease serum Mg levels in schizophrenia group as compared to control group (P=0.003).TSH levels were high in patient's depression.(P=0.076) and less Serum T 3 (P=0.000)and T 4 (P=0.000)was observed in depression group.serum Ca and Mg levels were significantly lower in depression group (P=0.000)(P=0.020)respectively.the serum Po 4 levels were significantly higher.(P=0.004)Conclusion: we concluded that in psychiatric disorder, thyroid hormones levels tend to be lower.This suggested hypo activity of thyroid gland.The study also reported decreased level of Ca & Mg and increased serum Po 4 levels.Derangement of the above minerals can lead to several complications.Thyroid hormones are responsible for regulation of the basal metabolic rate.Patients with psychiatric manifestations should be recommended screening for thyroid & mineral profile