染色质
生物
计算生物学
核糖核酸
相(物质)
细胞生物学
遗传学
DNA
物理
基因
量子力学
作者
Spiros Palikyras,Argyris Papantonis
出处
期刊:Open Biology
[The Royal Society]
日期:2019-10-01
卷期号:9 (10): 190167-190167
被引量:37
摘要
It has become evident that chromatin in cell nuclei is organized at multiple scales. Significant effort has been devoted to understanding the connection between the nuclear environment and the diverse biological processes taking place therein. A fundamental question is how cells manage to orchestrate these reactions, both spatially and temporally. Recent insights into phase-separated membraneless organelles may be the key for answering this. Of the two models that have been proposed for phase-separated entities, one largely depends on chromatin–protein interactions and the other on multivalent protein–protein and/or protein–RNA ones. Each has its own characteristics, but both would be able to, at least in part, explain chromatin and transcriptional organization. Here, we attempt to give an overview of these two models and their studied examples to date, before discussing the forces that could govern phase separation and prevent it from arising unrestrainedly.
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