活性氧
肿瘤微环境
谷胱甘肽
光热治疗
材料科学
氧化应激
光合作用
单线态氧
氧气
癌症研究
生物物理学
化学
纳米技术
生物化学
生物
肿瘤细胞
酶
有机化学
作者
Shiqiang Lu,Wei Feng,Xijuan Yao,Xinran Song,Jun Guo,Yu Chen,Zhongqian Hu
出处
期刊:Biomaterials
[Elsevier]
日期:2022-08-01
卷期号:287: 121688-121688
被引量:21
标识
DOI:10.1016/j.biomaterials.2022.121688
摘要
Nanodynamic therapy (NDT) based on reactive oxygen species (ROS) generation has been envisioned as a distinct modality for efficient cancer treatment. However, insufficient ROS generation and partial ROS consumption frequently limit the theraputic effect and outcome of NDT owing to the low oxygen (O2) tension and high glutathione (GSH) level in tumor microenvironment (TME). To circumvent these critical issues, we herein proposed and engineered the biodegradable GSH-depletion Mn(III)-riched manganese oxide nanospikes (MnOx NSs) with the photosynthetic bacterial cyanobacteria (Cyan) as a high-efficient and synergistic platform to reshape TME by simultaneously increasing oxygen content and decreasing GSH level. Specifically, under the trigger of acidity, MnOx NSs reacted with photosynthetic oxygen can generate toxic singlet oxygen (1O2). Moreover, MnOx NSs significantly reduced intracellular GSH, resulting in decreased GPX4 activity, which induced tumor cell non-apoptotic ferroptosis. Consequently, this combined strategy based on coadministration with Cyan and MnOx NSs demonstrated the superior antitumor efficacy via amplification of oxidative stress in 4T1 tumor-bearing mice for the synergetic oxygen-augmented nanodynamic/ferroptosis therapy. This work highlights a facile synergistic micro-/nano-system with the specific capability of reshaping TME to augment the sensitivity and therapeutic efficacy of NDT in solid hypoxic tumor therapy.
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