Effect of Musk with Borneol on Synapse ultrastructure in the rat model of cerebral focal ischemia with reperfusion

Objective:To investigate the effect of Musk with Borneol on Synapse ultrastructure in the rat model of cerebral focal ischemia with reperfusion.Methods:The model of MCAO-reperfusion was induced by the method of nylon monofilament via the internal carotid artery,electronic microscope was used to observe the changes of synapse in Cortex of parietal lobe.Results:After cerebral ischemia for 2 hours and reperfusion for 24 hours,the quantity of the synapses in neuropil of the model group decreased significantly(P0.01),and the typical synapse structure was destroyed;the quantity of the synapses in neuropil of Musk with Borneol group was significantly higher than that of the model group(P0.05)and the synapse form was almost normal.Conclusion:Musk with Borneol can increase the quantity of the synapses in neuropil and protect the Synapse ultrastructure after focal cerebral ischemia with reperfusion.