The expression and clinical significance of the IL-2 and IL-6 in serum and induced sputum in the children with Mycoplasma pneumoniae pneumonia

Objective To study the level of the IL-2 and IL-6 in serum and induced sputum in the children with mycoplasma pneumoniae pneumonia,then approach the role and clinical significance in the nosogenesis of the mycoplasma pneumoniae pneumonia.Methods Fifty-six children with mycoplasma pneumoniae pneumonia were collected from June 2009 to December 2010 in our hospital and the mass concentration of the IL-2 and IL-6 from fifty-six serum and forty-two induced sputum specimens was detected with enzyme linked immunosorbent assay,then the level of the IL-2 and IL-6 in serum and induced sputum were compared in different stages and mild and severe case with t-test.Results The level of the IL-2 of the children with mycoplasma pneumoniae pneumonia in serum and induced sputum in acute stage was lower than the convalescence stage and normal control group's(P 0.05).The level of the IL-6 was higher than the convalescence stage and normal control group's(P 0.05).The level of the IL-2 of the mild case with mycoplasma pneumoniae pneumonia in acute and convalescence stage was higher than the severe case's(P 0.05).The level of the IL-6 of the mild case was lower than the severe case's(P 0.05).The detection results of the two specimens from serum and induced sputum were accordant and the level of the IL-2 and IL-6 in induced sputum was higher than the level of the serum group,both positively related.Conclusion The level of the IL-2 and IL-6 in serum and induced sputum could be detected in infection incipient stage with mycoplasma pneumoniae so that the severity level and prognosis of the pathogenetic condition could be evaluated and judged.Meanwhile the evidences could be provided for the earlier immunologic intervention treatment.