Autophagy is also known as programmed type Ⅱ cell death. And autophagy has been shown to contribute to the occurrence and development of many diseases. More and more studies have suggested that the molecular regulation of autophagy and apoptosis pathways are inter-connected——numerous death stimuli are capable of activating either pathway, and both pathways share several genes, they can even transform with each other. A comprehensive study of the crosstalk between autophagy and apoptosis will bring a breakthrough on the cognition of the treatment of cancer and other diseases.