The expressions and its significance of MMP-3 and MMP-7 in malignant pleural effusion

Objective To detect the expressions of MMP-3 and MMP-7,assess the clinical significance in pleural effusion for directing clinical work.Methods The study included 89 cases of malignant pleural effusion as observation group and 50 cases of benign pleural effusion as control group.We detected the expressions of MMP-3 and MMP-7 by ELISA.Results Comparisons of the malignant and benign pleural effusion showed that there were significant up-regulations of MMP-3 and MMP-7 in the observation group.The expressions of MMP-3 and MMP-7 were associated with types of neoplasm.Conclusion The expressions of MMP-3 and MMP-7 have significant up-regulation in the malignant pleural effusion.MMP-3 and MMP-7 may play an important role in the malignant pleural effusion.The combined examination of MMP-3 and MMP-7 may be helpful to judge the type of neoplasm.