Nitric oxide donor-modified extracellular matrix hydrogel loaded with salvianolic acid B for diabetic wound healing

, the hydrogel accelerated wound closure, reduced inflammatory infiltration, promoted epidermal regeneration, and enhanced collagen deposition. Furthermore, it markedly upregulated the expression of angiogenesis-related markers, including hypoxia-inducible factor-1α (HIF-1α) and CD31, confirming its ability to stimulate neovascularization. By leveraging ECM as a bioactive NO carrier, this hydrogel platform enables the combined delivery of NO and Sal B, providing a multifunctional strategy for promoting diabetic wound healing.