PROCESS RELATED IMPURITIES IN THE PREPARATION OF OLMESARTAN MEDOXOMIL: AN-ANTIHYPERTENSIVE DRUG

Article history Olmesartan medoxomil is a prodrug within the class of angiotensin receptor antagonists, approved by the FDA for the treatment of hypertension. Present work describes the origin, synthesis and characterization of four process related novel impurities of olmesartan medoxomil viz. olmesartan chloro medoxomil, olmesartan medoxomil dimer, olmesartan diol and quaternary salt impurities.