Human Insulin Analog Insulin Aspart Does Not Cause Insulin Allergy

Human insulin is beneficial for most diabetic patients for whom insulin therapy is indispensable. However, some patients suffer from insulin allergy. Insulin allergies are immunologic reactions to exogenous insulin, which cause local or systemic symptoms. Here we report that insulin aspart, a human insulin analog, alleviated local and generalized insulin allergy in the absence of anti-allergic agents in a Japanese patient. A 59-year-old woman (60 kg body wt, BMI 24.4 kg/m2) with bronchial asthma was admitted to our hospital in December 2000 for the treatment of uncontrolled diabetes. She was first diagnosed as having type 2 diabetes in 1996 and started on treatment with oral hypoglycemic agents. However, hyperglycemia was difficult to control, and treatment with human …