选择性
环糊精
化学
高效液相色谱法
色谱法
手性柱色谱法
分析物
固定相
手性固定相
相(物质)
组合化学
有机化学
催化作用
作者
Randy A. Menges,Daniel W. Armstrong
出处
期刊:Acs Symposium Series
日期:1991-08-14
卷期号:: 67-100
被引量:35
标识
DOI:10.1021/bk-1991-0471.ch004
摘要
Cyclodextrin bonded stationary phases for HPLC have had a pronounced effect in the area of chiral separations. They are hydrolytically stable and have demonstrated unusual selectivity in the reversed and normal phase modes. Their selectivity is in part due to the inclusion complexation properties of cyclodextrins. Native and derivatized cyclodextrin bonded stationary phases have shown versatility for chiral separations. They are discussed in terms of their retention and chiral recognition mechanisms. Structural-selectivity relationships were observed for analytes using these columns. Optimization parameters are reviewed.
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