帕金森病
多巴胺能
神经科学
心理学
刺激
脑深部刺激
中枢神经系统疾病
退行性疾病
医学
内科学
多巴胺
疾病
作者
Kaja Kolmančič,N. Župančič,Maja Trošt,Dušan Flisar,Milica G. Kramberger,Zvezdan Pirtošek,Maja Kojović
摘要
In patients with advanced PD, switching from intermittent to continuous levodopa delivery increased corticospinal excitability and improved deficient intracortical inhibition and abnormal motor cortex plasticity, along with amelioration of motor fluctuations and dyskinesias. Continuous dopaminergic stimulation ameliorates maladaptive changes inflicted by chronic pulsatile dopaminergic stimulation. © 2022 International Parkinson and Movement Disorder Society.
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(2025-6-4)
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