High-dose megestrol acetate. A possible treatment for cachexia
医学
醋酸甲地孕酮
恶病质
甲地孕酮
厌食症
重症监护医学
内科学
癌症
作者
N. S. Tchekmedyian
出处
期刊:JAMA [American Medical Association] 日期:1987-03-06卷期号:257 (9): 1195-1198被引量:23
标识
DOI:10.1001/jama.257.9.1195
摘要
Weight loss and anorexia are significant complications of a variety of disorders and add morbidity to the underlying process. We observed marked weight gain (median, 5.1 kg; range, 0.9 to 20.1 kg) and appetite enhancement in 27 of the 28 patients with breast cancer receiving treatment consisting of high doses of oral megestrol acetate (480 to 1600 mg/d). Weight gain occurred regardless of pretreatment weight, extent of metastases, or response to therapy. Our results suggest a possible role for megestrol acetate in reversing anorexia and weight loss, thereby improving the quality of life of patients with cachexia. Further research is needed to establish the mechanism of weight gain and potential clinical applications. (JAMA1987;257:1195-1198)