丙二醛
药理学
超氧化物歧化酶
化学
消炎药
一氧化氮合酶
水肿
一氧化氮
抗氧化剂
过氧化氢酶
谷胱甘肽过氧化物酶
肿瘤坏死因子α
卡拉胶
生物化学
医学
免疫学
内科学
有机化学
作者
Jeng Shyan Deng,Szu-Wei Huang,Tsung Hui Lin,Min Min Lee,Ching Chuan Kuo,Ping Jyun Sung,Wen Chi Hou,Guan Jhong Huang,Yueh Hsiung Kuo
摘要
Eburicoic acid (TR1) and dehydroeburicoic acid (TR2), an active ingredient from Antrodia camphorata (AC) solid-state culture, were evaluated for analgesic and anti-inflammatory effects. Treatment with TR1 and TR2 significantly inhibited a number of acetic acid-induced writhing responses and formalin-induced pain in the late phase. In the anti-inflammatory test, TR1 and TR2 decreased paw edema at the fourth and fifth hour after λ-carrageenan (Carr) administration and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the paw edema tissue. We also demonstrated that TR1 and TR2 significantly attenuated the malondialdehyde (MDA), nitric oxide (NO), tumor necrosis factor (TNF-α), and interleukin-1β (IL-1β) levels in either edema paw or serum at the fifth hour after Carr injection. Western blotting revealed that TR1 and TR2 decreased Carr-induced inducible nitric oxide synthase (iNOS) and cycloxyclase (COX-2) expressions at the fifth hour in paw edema. Treatment with TR1 and TR2 also diminished neutrophil infiltration into the paw edema at the fifth hour. The present study suggests that the anti-inflammatory mechanisms of TR1 and TR2 might be related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity.
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