Expression of the murine Dlx-1 homeobox gene during facial, ocular and limb development

We have analysed the expression pattern of the mouse homeobox containing gene Dlx–1. This gene harbors a homeodomain related to that found in the Drosophila distal-less (dll) gene. In addition to its expression in the developing forebrain, Dlx-1 is transcribed in several structures containing cells of neural crest origin such as the facial mesenchyme and various elements of the peripheral nervous system. Dlx–1 transcripts are also detected in the differentiating retina and during limb morphogenesis, in the apical ectodermal ridge. The possible involvement of Dlx–1 during facial, ocular and limb development is discussed.