化学
表征(材料科学)
结合能
放松(心理学)
计算化学
结晶学
能量(信号处理)
物理化学
立体化学
纳米技术
原子物理学
量子力学
物理
心理学
社会心理学
材料科学
作者
Flaminia Cesare Marincola,Mariano Casu,Giuseppe Saba,Adolfo Laı̈,Per Lincoln,Bengt Nordén
标识
DOI:10.1016/s0301-0104(98)00199-2
摘要
Na-23 NMR relaxation rates were measured in Na-DNA aqueous solutions in the presence of Delta- or Lambda-enantiomer of [Ru(phen)(3)](2+) and [Ru(phen)(2)DPPZ](2+). From the analysis of the spin-lattice and spin-spin relaxation rates evidence is given that a decrease of the quadrupolar coupling constant for the slow motions occurs, due to the structural and dynamical modifications of DNA induced by the binding of the ruthenium complexes. Furthermore a linear dependence between the changes of the broad component, R-2bB, and the relative polyelectrolyte contributions to the binding free energy, Delta G(pe)/Delta G, was found. In particular for the intercalators Delta- and Lambda-[Ru(phen)(2)DPPZ](2+), a direct dependence on Delta G(pe)/Delta G was observed, as already found for ethidium, propidium and dq2pyp; while [Ru(phen)(3)](2+) complexes and the pure electrostatic Mg2+ showed an inverse dependence. These results have been discussed in terms of the polyelectrolyte interactions responsible for the R-2bB changes.
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