医学
优势比
置信区间
新生血管
内科学
糖尿病
糖化血红素
入射(几何)
胃肠病学
2型糖尿病
内分泌学
血管生成
光学
物理
作者
Lei Gao,Seung Jung Park,Yangsoo Jang,Stephen Lee,Chong Jin Kim,Yoshiyasu Minami,Daniel Ong,Tsunenari Soeda,Rocco Vergallo,Hang Lee,Bo Yu,Shiro Uemura,Ik Kyung Jang
标识
DOI:10.1016/j.jcin.2015.02.020
摘要
This study aimed to investigate the characteristics of neoatherosclerosis (NA) in patients with diabetes mellitus (DM) after drug-eluting stent (DES) implantation using optical coherence tomography.NA is an important substrate for stent failure. In vivo NA characteristics in DM patients have not been investigated.A total of 397 patients with 452 DES who underwent follow-up optical coherence tomography examination after DES implantation were enrolled. Characteristics of NA were compared between DM and non-DM patients. Neovascularization was defined as signal-poor holes or tubular structures with a diameter of 50 to 300 μm.A total of 123 DES with NA lesions in 115 patients were identified. The incidence of NA was similar between DM and non-DM patients (29.6% vs. 28.6%; p = 0.825). Compared with the non-DM group, neovascularization was more frequently observed in the DM group (55.1% vs. 32.4%; p = 0.012). The multivariate logistic model demonstrated that DM (odds ratio: 3.00; 95% confidence interval: 1.31 to 6.81; p = 0.009) and follow-up duration (odds ratio: 1.03; 95% confidence interval: 1.02 to 1.05; p < 0.001) were the independent predictors for neovascularization in NA lesions. DM patients with glycated hemoglobin ≥7.0% had a higher prevalence of thin-cap fibroatheroma compared with those with glycated hemoglobin <7.0% (40.0% vs. 8.3%; p = 0.01).The incidence of NA was similar between patients with and without DM. Neovascularization in NA lesions was more frequent in those with DM. Poorly controlled DM patients had a higher incidence of thin-cap fibroatheroma, compared with those with well-controlled DM.
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