PURPOSE: To determine the role of vitrectomy be used in retinal detachment uncomplicated by proliferative vitreoretinopathy (PVR). METHODS: We studied 54 cases who had undergone vitrectomy for retinal detachment uncomplicated by severe proliferative vitreoretinopathy. The indications for vitrectomy fell into three main groups: 1) retineal detachment of PVR-B (n = 15), 2) Retinal breaks at the posterior of PVR-C1 or C2 (n = 11), 3) retinal view was poor (n = 28). RESULTS: The success rate with one procedure was 74% and with further surgery retinal reattachment was achieved in 96%. After surgery, the visual acuity was improved in 43 eyes (79.6%) unchanged in 9 eyes (16.7%), and worse in 2 eyes (3.7%). CONCLUSION: Vitrectomy is an effective method for treatment of selected cases of retinal detachment uncomplicated by proliferative vitreoretinopathy.