Preparation of kaempferol cyclodextrin complex

Objective To prepare the hard-to-dissolve kaempferol-β-cyclodextrin complex and to increase the solubility of kaempferol,so as to broaden the ways of kaempferol medication.Methods Trituration was used to prepare kaempferol- hydroxypropyl-β-cyclodextrins and the kaempferol-β-cyclodextrin complex.The PXRD,differential scanning calorimetry(DSC) and infrared spectrometry (IR) were used to identify and characterize the prepared complex.Results Complexes were derived respectively from kaempferol, hydroxypropyl-β-cyclodextrins,andβ-cyclodextrin.Solubility research both before and after the formation of the complexes showed that the solubility of kaempferol after the formation of the complex increased by 26.7 and 9.7 times respectively.Conclusion The preparation method of kaempferol-β-cyclodextrin complex was simple and practical,and could enable further development and application of kaempferol.