Influence of radiotherapy lession on T-Lymphocyte subsets in peripheral blood of the mice

Objective: To analysize the changes in T-Lymphocyte Subsets in peripheral blood of the mice,and investigate the cellular and molecular mechanism of immune system injury induced by irradiation.Methods: The peripheral blood was collected from different radiotherapy dose of the mice.The changes of T-lymphocyte subsets CD3+,CD4+,CD8+ and CD4+CD25highregulatory T cells were analyzed by flow cytometry.Results: TheT lymphocyte subsets CD3+,CD4+,CD8+ have distinctly reduced after irradiation(P0.05);CD4+CD25highregulatory T cells shows marked increase compared with that the control group(P0.05).Conclusion: The radiotherapy can inhibit T lymphocyte subsets in mice which can be a useful index for monitoring the immunity function.