Engineering Injectable Coassembled Hydrogel by Photothermal Driven Chitosan-Stabilized MoS2 Nanosheets for Infected Wound Healing

The application of enzyme-like molybdenum disulfide (MoS 2 ) in tissue repair was confronted with stable dispersion, solubilization, and biotoxicity. Here, the injectable self-healing hydrogel was successfully designed using a step-by-step coassembly of chitosan and MoS 2 . Polyphenolic chitosan as a “structural stabilizer” of MoS 2 nanosheets reconstructed well-dispersed MoS 2 @CSH nanosheets, which improved the biocompatibility of traditional MoS 2, and strengthened its photothermal conversion and enzyme-like activities, guaranteeing highly efficient radical scavenging and antimicrobial properties. Furthermore, the polyphenol chitosan was employed again as a “molecular cross-linking agent” to form the injectable NIR-responsive MoS 2 @CSH hydrogel by accelerating hydrogen-bond interaction among chitosan and the multicross-linking reaction among polyphenols. The rapid self-healing ability was conducive to wound closure and dynamic adaptability. An experimental study on infected wound healing demonstrated that MoS 2 @CSH hydrogel could substantially eradicate bacteria and accelerate the angiogenesis of infected wounds. The photothermal-driven coassembly of MoS 2 and polycation provided an alternative strategy for infected wound healing.