[Research progress on uranium induced human renal injury and its risk prediction].

Uranium has both radiotoxicity and chemical toxicity. Low enriched uranium is mainly chemically toxic, the kidney is the target organ of uranium chemical toxicity. However, due to the differences among species and the mixed effects of chemical toxicity and radiotoxicity, the dose effect relationship of uranium is not clear, and the current standards in China do not provide chemical toxicity limits for uranium workplaces. This paper reviews the data of acute and chronic human uranium exposure, dose effect relationship and renal injury risk prediction literature at home and abroad, providing reference for the health protection of uranium workers and the establishment of chemical limits in uranium workplaces.铀同时具有放射性毒性和化学毒性，低浓度铀以化学毒性为主，肾脏是铀化学毒性的靶器官。但由于物种间差异及其化学毒性和放射性毒性的混合效应，铀剂量效应关系并不明确，我国现行标准也未提供铀作业场所化学毒性限值。本文对国内外人类急性及慢性铀暴露资料及其剂量效应关系、肾脏损伤风险预测文献进行综述，为铀作业人员的健康防护及铀作业场所的化学限值制定提供参考。.