叶黄素
水苏糖
生物利用度
化学
低聚糖
食品科学
色谱法
生物化学
药理学
医学
类胡萝卜素
棉子糖
蔗糖
作者
Yuanyuan Li,Bingxue Liu,Xiaoxue Zhang,Yanjie Liu,Siying Wang,Shujun Li,Xiuhua Zhao
标识
DOI:10.1016/j.foodchem.2023.136032
摘要
A new amphiphilic oligosaccharide derivative, based on lutein modification onto the OH position of stachyose with facile and mild esterification, was prepared and used to improve the oral bioavailability of lutein. The structures of lutein-stachyose derivative (LS) were confirmed by Fourier transform infrared spectroscopy and hydrogen-1 nuclear magnetic resonance, indicating that one stachyose is connected to one lutein through succinic acid. The critical micelle concentration of LS was approximately 6.86 ± 0.24 mg/mL, corresponding to the free lutein concentration of approximately 2.96 mg/mL. LS has better digestive stability and free radical scavenging ability, and it could inhibit the degradation of lutein in the gastrointestinal tract. Importantly, LS is nontoxic to cells and zebrafish embryos. In terms of oral bioavailability in rats, the AUC0-12h values of LS were 2.26 times higher than those of free lutein. Therefore, stachyose modification is a promising strategy for improving the oral bioavailability of fat-soluble lutein.
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