自身免疫
调节器
免疫学
免疫
生物
转录因子
炎症
调解人
免疫系统
细胞因子
细胞生物学
遗传学
基因
作者
Melissa E. Cook,Nicholas N. Jarjour,Chih Chung Lin,Brian T. Edelson
标识
DOI:10.1016/j.it.2020.09.002
摘要
The basic helix-loop-helix transcription factor (TF) Bhlhe40 is emerging as a key regulator of immunity during infection, autoimmunity, and inflammatory conditions. We describe the roles of Bhlhe40 in the circulating and tissue-resident arms of the immune system, with emphasis on recent work on the regulation of cytokine production and proliferation. We explore the mechanisms behind these functions in mouse models and human cells, including interactions with other TFs, and propose that Bhlhe40 is a central mediator of both inflammation and pathogen control, as well as a crucial regulator of a growing number of tissue-resident leukocyte populations. Finally, we suggest areas for further study that may advance our understanding of immunity and disease.
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