The mechanisms of nutrient-stimulated GLP-1 secretion from intestinal L-cells

In response to the stimulation of nutrients,glucagon-like peptide-1 (GLP-1) is secreted from the intestinal epithelial L-cells,which is important to postprandial plasma glucagon modulation and appetite control.The nutrients include carbohydrates,proteins and lipids.Carbohydrates stimulate GLP-1 release from L-cells by ATP-sensitive K+ channel( KATP channel),sodium-glucose cotransporter(SGLT) 1 and taste receptor pathways.Proteins stimulate GLP-1 release from L-cells by plasma membrane depolarization which is initiated by voltage gated Ca2 + -channels,Na+ -K + -2Cl - cotransporters,ionotropic GABA receptor and Na + -coupled transporters,while lipids stimulate GLP-1 release from L-cells by fatty acids-sensitive G-protein coupled receptors. Key words: Nutrients;  L cells;  Glucagon-like peptide-1