石蒜科
差向异构体
生物碱
丁酰胆碱酯酶
立体化学
化学
石蒜科生物碱
对接(动物)
阿切
酶
植物
生物
乙酰胆碱酯酶
生物化学
医学
护理部
作者
Luciana R. Tallini,Edison Osorio,Vanessa Dias dos Santos,Warley de Souza Borges,Marcel Kaiser,Françesc Viladomat,José Ângelo Silveira Zuanazzi,Jaume Bastida
出处
期刊:Molecules
[MDPI AG]
日期:2017-12-09
卷期号:22 (12): 2191-2191
被引量:21
标识
DOI:10.3390/molecules22122191
摘要
The Amaryllidaceae family has proven to be a rich source of active compounds, which are characterized by unique skeleton arrangements and a broad spectrum of biological activities. The aim of this work was to perform the first detailed study of the alkaloid constituents of Hippeastrum reticulatum (Amaryllidaceae) and to determine the anti-parasitological and cholinesterase (AChE and BuChE) inhibitory activities of the epimers (6α-hydroxymaritidine and 6β-hydroxymaritidine). Twelve alkaloids were identified in H. reticulatum: eight known alkaloids by GC-MS and four unknown (6α-hydroxymaritidine, 6β-hydroxymaritidine, reticulinine and isoreticulinine) by NMR. The epimer mixture (6α-hydroxymaritidine and 6β-hydroxymaritidine) showed low activity against all protozoan parasites tested and weak AChE-inhibitory activity. Finally, a molecular docking analysis of AChE and BuChE proteins showed that isoreticulinine may be classified as a potential inhibitory molecule since it can be stabilized in the active site through hydrogen bonds, π-π stacking and hydrophobic interactions.
科研通智能强力驱动
Strongly Powered by AbleSci AI