Global Trends and Collaborative Networks in Serotonin-Mediated PainModulation Research: A Scoping Review and Bibliometric Analysis

INTRODUCTION: Serotonin plays a critical role in pain modulation, making it a significant target for understanding and managing pain. Analyzing the most impactful publications can provide valuable insights into the intellectual structure, key contributors, and collaborative networks that have shaped the current state of knowledge in this field. METHODS: A systematic review and bibliometric analysis were conducted using the Scopus database, identifying 856 articles related to serotonin-mediated pain modulation. After applying the inclusion criteria, the top 100 most-cited articles published between 1999 and 2021 were selected, representing a total of 33,500 citations. Citation metrics, publication years, authorship, institutions, countries, and journals were analyzed. Additionally, co-citation, keyword co-occurrence, and collaboration network analyses were performed to map the intellectual structure and collaborative patterns within the field. RESULTS: The United States led contributions with 28% of publications, followed by France (15%) and Japan (12%). The 100 most-cited articles appeared across 45 journals, predominantly in Pain (15 articles) and Neuroscience (10 articles). Five major author clusters were identified, with key figures such as Hamon M., Yaksh T.L., and Porreca F. collectively accounting for over 5,000 citations. Four thematic keyword clusters, including "serotonin receptors," "analgesia," and "nociception," were identified. International collaborations accounted for 65% of the publications. DISCUSSION: The findings highlight the global and interdisciplinary nature of research on serotoninmediated pain modulation. Prominent research hubs, key contributors, and collaborative international networks have significantly shaped the field's development. The identified trends and thematic areas provide valuable insight into the evolving landscape of neuropharmacology and pain research. CONCLUSION: This systematic review and bibliometric analysis provide a comprehensive overview of serotonin-mediated pain modulation research, emphasizing the importance of international collaboration and offering direction for future investigations into therapeutic strategies targeting serotonergic mechanisms in pain management.