Ultrasound-activated dual-targeted liposomes for visualized precise neuromodulation against myocardial ischemia-reperfusion injury

studies confirmed that BT@Lip-TN enabled functional NIR-II imaging and real-time monitoring of neuroinflammatory activity. Furthermore, BT@Lip-TN-mediated targeted sonodynamic neuromodulation suppressed sympathetic neuroinflammation and ameliorating myocardial I/R injury. This study pioneers the design of neuroinflammatory dual-targeted sonosensitizer and establishes an integrated theranostic platform, offering novel insights into visualized precise neuromodulation and the treatment of myocardial I/R injury.