类有机物
视网膜
视网膜
神经科学
诱导多能干细胞
生物
生物化学
胚胎干细胞
基因
作者
Jessica R. Onyak,M. Natalia Vergara,Jordan M. Renna
标识
DOI:10.1016/j.trsl.2022.06.001
摘要
The ability to generate human retinas in vitro from pluripotent stem cells opened unprecedented opportunities for basic science and for the development of therapeutic approaches for retinal degenerative diseases. Retinal organoid models not only mimic the histoarchitecture and cellular composition of the native retina, but they can achieve a remarkable level of maturation that allows them to respond to light stimulation. However, studies evaluating the nature, magnitude, and properties of light-evoked responsivity from each cell type, in each retinal organoid layer, have been sparse. In this review we discuss the current understanding of retinal organoid function, the technologies used for functional assessment in human retinal organoids, and the challenges and opportunities that lie ahead.
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