三阴性乳腺癌
微泡
转移
癌症研究
小RNA
异位表达
阿霉素
乳腺癌
癌症
细胞凋亡
Oncomir公司
医学
生物
内科学
细胞培养
化疗
癌变
基因
生物化学
遗传学
作者
Yaming Li,Yiran Liang,Yuting Sang,Xinwei Song,Hanwen Zhang,Ying Liu,Liyu Jiang,Qifeng Yang
标识
DOI:10.1038/s41419-017-0030-7
摘要
Abstract Chemo-resistance and metastasis of triple negative breast cancer (TNBC) contributed the most of treatment failure in the clinic. MicroRNAs (miRNAs) have been proved to be involved in many biological processes and diseases. In this study, we aimed to determine the role of miR-770 in the regulation of chemo-resistance and metastasis of TNBC. Clinically, miR-770 was highly expressed in chemo-sensitive tissues and predicted a better prognosis of TNBC. Functionally, ectopic expression of miR-770 suppressed the doxorubicin-resistance of TNBC cell lines via regulation of apoptosis and tumor microenvironment, which was mediated by exosomes. Moreover, miR-770 overexpression inhibited the migration and invasion. Rescue of STMN1 could partly reverse the effect of miR-770 in TNBC behaviors. Furthermore, we also demonstrated that overexpression of miR-770 inhibited DOX resistance and metastasis in vivo. Taken together, our results proved that miR-770 could suppress the doxorubicin-resistance and metastasis of TNBC cells, which broaden our insights into the underlying mechanisms in chemo-resistance and metastasis, and provided a new prognostic marker for TNBC cells.
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