Synthesis of some new N1-[(2-oxo-3-chloro-4-aryl-azitidin)-(acetyl amino)]-indole derivatives and their pharmacological activity

Indole on reaction with chloroacetyl chloride afforded N 1 -(1-chloro acetyl)-indole which was refluxed with hydrazine hydrate to give N 1 -[(1-hydrazinolacetyl]-indole. The hydrazino derivative of indole was further treated with various substituted aromatic carbonyls to get N 1 -[(benzylidene hydrazino)-acetyl]-indoles (3a-j). The compounds 3a-j were treated with chloroacetyl chloride in presence of Et 3 N to afford N 1 -[(2-oxo-3-chloro-4-aryl-azitidin)-(acetyl amino)]-indoles, 4a-j. The structures of all the compounds were elucidated by elemental analysis, IR and 1 H NMR spectrometry. All the compounds were screened for their antimicrobial, anti-inflammatory and anticonvulsant activities.