下调和上调
CYP27A1
细胞凋亡
癌症研究
体内
肾细胞癌
细胞
生物
化学
新陈代谢
内科学
内分泌学
医学
生物化学
遗传学
基因
作者
Xingming Zhang,Xiaoxue Yin,Jindong Dai,Guangxi Sun,Haoran Zhang,Jiayu Liang,Jinge Zhao,Sha Zhu,Junru Chen,Xudong Zhu,Yuchao Ni,Zhipeng Wang,Zhenhua Liu,Ni Chen,Pengfei Shen,Hao Zeng
标识
DOI:10.1096/fj.202101146rr
摘要
As a key approach to mediate cholesterol metabolism, the role of the CYP27A1/27-HC axis in renal cell carcinoma (RCC) remains unclear. Analysis of CYP27A1 expression from public databases and metastatic cases in our center suggested that CYP27A1 was obviously downregulated in RCC tissues, and survival analysis further showed its correlation with favorable clinicopathological features and prognosis. In vitro, up and downregulation of CYP27A1 expression in RCC cell lines could definitely illustrate its anticipation involving apoptosis, proliferation, invasion, migration, and clonality. This could be achieved through upregulation of 27-HC concentration, which mediates the activation of signaling pathways of apoptosis and cell cycle arrest. Further, recovery of CYP27A1 expression could definitely inhibit the proliferation of RCC tumors in vivo. This is the first study to explore the role of the CYP27A1/27-HC axis in RCC. Attempts to maintain the normal function of the axis may be a potential strategy in the treatment of RCC, and the predictive value of CYP27A1 detection on the efficacy of targeted therapy in metastatic RCC is also worthy of attention.
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